Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P29083
UPID:
T2EA_HUMAN
Alternative names:
General transcription factor IIE 56 kDa subunit; Transcription initiation factor IIE subunit alpha
Alternative UPACC:
P29083; Q16103
Background:
General transcription factor IIE subunit 1, also known as the 56 kDa subunit or transcription initiation factor IIE subunit alpha, plays a pivotal role in gene expression. It recruits TFIIH to the initiation complex, enhancing RNA polymerase II's kinase and DNA-dependent ATPase activities, crucial for promoter clearance.
Therapeutic significance:
Understanding the role of General transcription factor IIE subunit 1 could open doors to potential therapeutic strategies.