Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P29460
UPID:
IL12B_HUMAN
Alternative names:
Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; NK cell stimulatory factor chain 2
Alternative UPACC:
P29460
Background:
Interleukin-12 subunit beta, also known as IL-12 subunit p40, plays a pivotal role in the immune system. It acts as a growth factor for activated T and NK cells, enhances NK cell activity, and stimulates IFN-gamma production. This cytokine, in association with IL23A, forms the IL-23 interleukin, crucial for both innate and adaptive immunity. IL-23 promotes pro-inflammatory cytokine production and is vital in autoimmune inflammation and potentially in tumorigenesis.
Therapeutic significance:
Interleukin-12 subunit beta is implicated in Immunodeficiency 29 and Psoriasis 11, diseases characterized by impaired immunity and chronic inflammation, respectively. Understanding its role could lead to novel treatments for these conditions, highlighting its therapeutic significance in modulating immune responses and inflammation.