Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P30040
UPID:
ERP29_HUMAN
Alternative names:
Endoplasmic reticulum resident protein 28; Endoplasmic reticulum resident protein 31
Alternative UPACC:
P30040; C9J183; Q3MJC3; Q6FHT4
Background:
Endoplasmic reticulum resident protein 29, also known as Endoplasmic reticulum resident protein 28 and 31, plays a crucial role in the processing of secretory proteins within the endoplasmic reticulum (ER). Despite not acting as a disulfide isomerase, it significantly contributes to the folding of proteins in the ER, ensuring proper protein configuration and functionality.
Therapeutic significance:
Understanding the role of Endoplasmic reticulum resident protein 29 could open doors to potential therapeutic strategies. Its pivotal function in protein folding within the ER highlights its importance in cellular physiology and presents a unique target for therapeutic intervention in diseases related to protein misfolding.