Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P30043
UPID:
BLVRB_HUMAN
Alternative names:
Biliverdin reductase B; Biliverdin-IX beta-reductase; Green heme-binding protein; NADPH-dependent diaphorase; NADPH-flavin reductase
Alternative UPACC:
P30043; A6NKD8; B2R5C6; P32078; P53005; Q32LZ2
Background:
Flavin reductase (NADPH), also known as Biliverdin reductase B, plays a crucial role in the body's metabolic processes. It exhibits broad specificity, catalyzing the NADPH-dependent reduction of various flavins, biliverdins, methemoglobin, and PQQ. This enzyme is pivotal in heme catabolism and the metabolism of linear tetrapyrroles, also facilitating the reduction of Fe(3+) to Fe(2+) in the liver, aiding in the conversion of biliverdin to bilirubin.
Therapeutic significance:
Understanding the role of Flavin reductase (NADPH) could open doors to potential therapeutic strategies.