Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P31153
UPID:
METK2_HUMAN
Alternative names:
Methionine adenosyltransferase 2; Methionine adenosyltransferase II
Alternative UPACC:
P31153; A8K511; B4DN45; D6W5L1; Q53SP5
Background:
S-adenosylmethionine synthase isoform type-2, also known as Methionine adenosyltransferase 2, plays a pivotal role in cellular metabolism. It catalyzes the essential reaction of methionine and ATP to form S-adenosylmethionine (AdoMet), a critical methyl donor involved in numerous metabolic processes. This enzyme's activity is crucial for the synthesis of polyamines, nucleic acids, proteins, and lipids.
Therapeutic significance:
Understanding the role of S-adenosylmethionine synthase isoform type-2 could open doors to potential therapeutic strategies. Its central role in methylation processes makes it a potential target for interventions in metabolic disorders, offering a promising avenue for drug discovery and development.