Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P32246
UPID:
CCR1_HUMAN
Alternative names:
HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; RANTES-R
Alternative UPACC:
P32246; Q86VA9
Background:
C-C chemokine receptor type 1 (CCR1), also known by alternative names such as HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, and RANTES-R, plays a pivotal role in the immune system. It functions as a receptor for C-C type chemokines, binding to a variety of ligands including MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3. This interaction is crucial for transducing signals that increase intracellular calcium ions level, influencing stem cell proliferation.
Therapeutic significance:
Understanding the role of C-C chemokine receptor type 1 could open doors to potential therapeutic strategies. Its involvement in signal transduction and stem cell proliferation highlights its potential as a target in modulating immune responses and regenerative medicine.