Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P33552
UPID:
CKS2_HUMAN
Alternative names:
-
Alternative UPACC:
P33552; Q6FGI9; Q6LET5
Background:
Cyclin-dependent kinases regulatory subunit 2 plays a pivotal role in cell cycle regulation by binding to the catalytic subunit of cyclin-dependent kinases. This interaction is crucial for the activation of CDKs and the progression of the cell cycle, highlighting its fundamental role in cellular division and growth.
Therapeutic significance:
Understanding the role of Cyclin-dependent kinases regulatory subunit 2 could open doors to potential therapeutic strategies. Its essential function in cell cycle regulation positions it as a key target for developing treatments aimed at controlling cell proliferation in various diseases.