Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P35613
UPID:
BASI_HUMAN
Alternative names:
5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; Hepatoma-associated antigen; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor
Alternative UPACC:
P35613; A6NJW1; D3YLG5; Q7Z796; Q8IZL7
Background:
Basigin, also known as BSG or CD147, is a multifunctional transmembrane protein involved in various physiological and pathological processes. It plays a crucial role in retinal development, acting as a receptor for NXNL1 to support the survival of retinal cone photoreceptors. Basigin is also pivotal in enhancing aerobic glycolysis in photoreceptors, facilitating glucose entry. Additionally, it serves as a receptor for erythrocyte invasion by P. falciparum, contributing to malaria pathogenesis. Its interaction with cyclophilins is essential for immune cell chemotaxis and adhesion.
Therapeutic significance:
Understanding the role of Basigin could open doors to potential therapeutic strategies. Its involvement in retinal health, immune response, and disease pathogenesis, including malaria and viral infections, highlights its potential as a target for therapeutic intervention. Developing inhibitors or modulators of Basigin could lead to novel treatments for a range of conditions.