Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P37231
UPID:
PPARG_HUMAN
Alternative names:
Nuclear receptor subfamily 1 group C member 3
Alternative UPACC:
P37231; A8K3G6; B5BUA1; O00684; O00710; O14515; Q0QJH8; Q15178; Q15179; Q15180; Q15832; Q86U60; Q96J12
Background:
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that plays a pivotal role in the regulation of fatty acid storage and glucose metabolism. PPARγ is a key regulator of adipocyte differentiation and is instrumental in the control of the peroxisomal beta-oxidation pathway of fatty acids. It also has a significant role in suppressing NF-kappa-B-mediated pro-inflammatory responses, thereby maintaining gut homeostasis.
Therapeutic significance:
PPARγ's involvement in diseases such as obesity, familial partial lipodystrophy, and glioma highlights its potential as a therapeutic target. Its role in regulating glucose homeostasis and adipocyte differentiation makes it a promising candidate for the development of treatments for metabolic disorders. Additionally, its association with glioma susceptibility suggests a possible avenue for cancer therapy.