Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P39019
UPID:
RS19_HUMAN
Alternative names:
40S ribosomal protein S19
Alternative UPACC:
P39019
Background:
Small ribosomal subunit protein eS19, also known as 40S ribosomal protein S19, plays a crucial role in protein synthesis. It is a component of the small ribosomal subunit, essential for pre-rRNA processing and the maturation of 40S ribosomal subunits. This protein is involved in the intricate process of assembling the SSU processome in the nucleolus, facilitating RNA folding, modifications, and cleavage.
Therapeutic significance:
The association of Small ribosomal subunit protein eS19 with Diamond-Blackfan anemia 1, a congenital non-regenerative hypoplastic anemia, underscores its therapeutic significance. Understanding the role of this protein could lead to novel therapeutic strategies for treating this form of anemia, which is characterized by macrocytic anemia, erythroblastopenia, and an increased leukemia risk.