Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P41587
UPID:
VIPR2_HUMAN
Alternative names:
Helodermin-preferring VIP receptor; Pituitary adenylate cyclase-activating polypeptide type III receptor; VPAC2
Alternative UPACC:
P41587; Q13053; Q15870; Q53Y09; Q6ZN22; Q9UCW0
Background:
Vasoactive intestinal polypeptide receptor 2 (VIPR2), also known as the Helodermin-preferring VIP receptor, plays a crucial role in cellular signaling. It acts as a receptor for VIP and PACAP peptides, activating adenylyl cyclase through G protein mediation. This activation can also be linked to phospholipase C pathways, showcasing its versatile signaling capabilities.
Therapeutic significance:
Understanding the role of Vasoactive intestinal polypeptide receptor 2 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways highlights its potential as a target for drug discovery, aiming to modulate cellular responses in various conditions.