Focused On-demand Library for Large ribosomal subunit protein uL29

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

P42766

UPID:

RL35_HUMAN

Alternative names:

60S ribosomal protein L35

Alternative UPACC:

P42766; A8K4V7; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4

Background:

The Large ribosomal subunit protein uL29, also known as 60S ribosomal protein L35, plays a crucial role in protein synthesis. As a component of the large ribosomal subunit, it is integral to the ribosome's function, a complex responsible for translating mRNA into proteins within the cell. This process is fundamental to all cellular operations and organismal development.

Therapeutic significance:

Diamond-Blackfan anemia 19, a congenital non-regenerative hypoplastic anemia, has been linked to variants affecting the gene encoding Large ribosomal subunit protein uL29. Understanding the role of Large ribosomal subunit protein uL29 could open doors to potential therapeutic strategies for this condition, which presents with macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.