Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P43250
UPID:
GRK6_HUMAN
Alternative names:
G protein-coupled receptor kinase GRK6
Alternative UPACC:
P43250; O60541; Q13652
Background:
G protein-coupled receptor kinase 6 (GRK6) plays a pivotal role in cellular signaling by specifically phosphorylating activated forms of G protein-coupled receptors. This action triggers beta-arrestin-mediated receptor desensitization, internalization, and subsequent signaling events. GRK6 is instrumental in the desensitization of D2-like dopamine receptors in the striatum and the chemokine receptor CXCR4, essential for CXCL12-induced cell chemotaxis. Additionally, it phosphorylates rhodopsin and LRP6 during Wnt signaling.
Therapeutic significance:
Understanding the role of G protein-coupled receptor kinase 6 could open doors to potential therapeutic strategies.