Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P43351
UPID:
RAD52_HUMAN
Alternative names:
-
Alternative UPACC:
P43351; Q13205; Q9Y5T7; Q9Y5T8; Q9Y5T9
Background:
The DNA repair protein RAD52 homolog plays a pivotal role in the maintenance of genomic integrity. It is essential for double-stranded break repair, facilitating the annealing of complementary single-stranded DNA. RAD52 also enhances the activity of RAD51, a recombinase vital for genetic recombination and DNA repair processes.
Therapeutic significance:
Understanding the role of DNA repair protein RAD52 homolog could open doors to potential therapeutic strategies. Its central function in DNA repair and genetic recombination positions it as a key target for interventions in diseases where these processes are compromised.