Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P43490
UPID:
NAMPT_HUMAN
Alternative names:
Pre-B-cell colony-enhancing factor 1; Visfatin
Alternative UPACC:
P43490; A4D0Q9; A4D0R0; Q3KQV0; Q8WW95
Background:
Nicotinamide phosphoribosyltransferase, known as NAMPT and also referred to as Pre-B-cell colony-enhancing factor 1 or Visfatin, plays a pivotal role in the biosynthesis of NAD. It catalyzes the formation of nicotinamide mononucleotide, a crucial intermediate in NAD biosynthesis, acting as the rate-limiting component in this pathway. Beyond its enzymatic function, NAMPT exhibits cytokine and adipokine activity, influencing immunomodulation and anti-diabetic effects, respectively. It also contributes to the regulation of the circadian clock by modulating the oscillatory production of NAD, which in turn affects clock gene expression.
Therapeutic significance:
Understanding the role of Nicotinamide phosphoribosyltransferase could open doors to potential therapeutic strategies.