Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P43628
UPID:
KI2L3_HUMAN
Alternative names:
CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; NKAT2a; NKAT2b; Natural killer-associated transcript 2; p58 natural killer cell receptor clone CL-6; p58.2 MHC class-I-specific NK receptor
Alternative UPACC:
P43628; O43472; P78402; Q14944; Q14945; Q9UM51; Q9UQ70
Background:
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) functions as a receptor on natural killer (NK) cells for HLA-C alleles, including HLA-Cw1, HLA-Cw3, and HLA-Cw7. By inhibiting the activity of NK cells, KIR2DL3 plays a crucial role in preventing cell lysis. This protein is also known by several alternative names, such as CD158 antigen-like family member B2 and NKAT2a, highlighting its significance in immune regulation.
Therapeutic significance:
Understanding the role of Killer cell immunoglobulin-like receptor 2DL3 could open doors to potential therapeutic strategies. Its ability to regulate NK cell activity positions it as a key player in the immune response, offering pathways for interventions in diseases where NK cell function is pivotal.