Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P46059
UPID:
S15A1_HUMAN
Alternative names:
Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; Peptide transporter 1
Alternative UPACC:
P46059; Q5VW82
Background:
Solute carrier family 15 member 1 (SLC15A1), also known as Peptide transporter 1, plays a crucial role in nutrient absorption. It is an electrogenic proton-coupled amino-acid transporter, primarily facilitating the uptake of di- and tripeptides from the small intestinal lumen. Its ability to transport neutral and monovalently charged peptides, with a proton to peptide stoichiometry of 1:1 or 2:1, underscores its significance in digestive health. Additionally, SLC15A1 mediates the transepithelial transport of bacterial dipeptides, aiding in the mucosal immune system's recognition of pathogenic bacteria.
Therapeutic significance:
Understanding the role of Solute carrier family 15 member 1 could open doors to potential therapeutic strategies, particularly in enhancing nutrient absorption and bolstering mucosal immunity.