Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P46100
UPID:
ATRX_HUMAN
Alternative names:
ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; Znf-HX
Alternative UPACC:
P46100; D3DTE2; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3
Background:
The Transcriptional Regulator ATRX, known for its roles in transcriptional regulation and chromatin remodeling, is pivotal in DNA replication and genomic stability. It binds to DNA tandem repeat sequences, facilitating the incorporation of histone H3.3 and remodeling G4 DNA. As a catalytic component of the ATRX:DAXX chromatin remodeling complex, ATRX is essential for the deposition of histone H3.3 in pericentric DNA repeats and telomeres, contributing to telomere integrity and genomic fidelity.
Therapeutic significance:
ATRX mutations are linked to severe disorders like Alpha-thalassemia/impaired intellectual development syndrome, X-linked, and Intellectual disability-hypotonic facies syndrome, X-linked, 1. Understanding the role of ATRX could open doors to potential therapeutic strategies, offering hope for targeted treatments in genetic disorders and cancer, where ATRX function is compromised.