Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P46783
UPID:
RS10_HUMAN
Alternative names:
40S ribosomal protein S10
Alternative UPACC:
P46783; B2R4E3; Q5TZC0
Background:
Small ribosomal subunit protein eS10, alternatively known as 40S ribosomal protein S10, plays a crucial role in the 40S ribosomal subunit. This protein is integral to the ribosome, a large ribonucleoprotein complex responsible for protein synthesis within the cell. Its involvement in the cellular machinery underscores its importance in biological processes.
Therapeutic significance:
Small ribosomal subunit protein eS10 is linked to Diamond-Blackfan anemia 9, a congenital non-regenerative hypoplastic anemia. Understanding the role of Small ribosomal subunit protein eS10 could open doors to potential therapeutic strategies for this condition, which presents with macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.