Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P47813
UPID:
IF1AX_HUMAN
Alternative names:
Eukaryotic translation initiation factor 4C
Alternative UPACC:
P47813; B2R5U5; Q0VGC2; Q5JPS5; Q5JPS6
Background:
Eukaryotic translation initiation factor 1A, X-chromosomal, also known as Eukaryotic translation initiation factor 4C, plays a pivotal role in the initiation phase of protein synthesis. It is a key component of the 43S pre-initiation complex, aiding in mRNA scanning, start codon recognition, and the assembly of the 48S complex. This protein's interaction with EIF5 during scanning maintains EIF1 within the open 43S PIC, facilitating the transition to the 80S initiation complex upon start codon location.
Therapeutic significance:
Understanding the role of Eukaryotic translation initiation factor 1A, X-chromosomal could open doors to potential therapeutic strategies.