Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
P47898
UPID:
5HT5A_HUMAN
Alternative names:
Serotonin receptor 5A
Alternative UPACC:
P47898; Q2M2D2
Background:
The 5-hydroxytryptamine receptor 5A, also known as the Serotonin receptor 5A, plays a pivotal role in neurotransmission and hormonal regulation. This receptor, encoded by the gene with accession number P47898, is integral to the modulation of serotonin, a key neurotransmitter involved in a myriad of physiological processes. The receptor's activity is mediated through G proteins, highlighting its importance in signal transduction pathways.
Therapeutic significance:
Understanding the role of 5-hydroxytryptamine receptor 5A could open doors to potential therapeutic strategies. Its involvement in serotonin signaling makes it a compelling target for the development of drugs aimed at treating neurological and psychiatric conditions.