Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P47985
UPID:
UCRI_HUMAN
Alternative names:
Complex III subunit 5; Cytochrome b-c1 complex subunit 5; Rieske iron-sulfur protein; Rieske protein UQCRFS1; Ubiquinol-cytochrome c reductase iron-sulfur subunit
Alternative UPACC:
P47985; A8K519; Q6NVX5; Q9UPH2
Background:
The Cytochrome b-c1 complex subunit Rieske, mitochondrial, known as UQCRFS1, plays a pivotal role in the mitochondrial electron transport chain. This protein is a component of the ubiquinol-cytochrome c oxidoreductase complex, essential for oxidative phosphorylation. It facilitates the transfer of electrons from ubiquinol to cytochrome c, a critical step in the generation of ATP, the cell's energy currency.
Therapeutic significance:
Mutations in UQCRFS1 are linked to Mitochondrial complex III deficiency, nuclear type 10, manifesting in symptoms like hypertrophic cardiomyopathy and lactic acidosis. Understanding the role of UQCRFS1 could open doors to potential therapeutic strategies for this condition, highlighting its importance in medical research.