Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49005
UPID:
DPOD2_HUMAN
Alternative names:
DNA polymerase delta subunit p50
Alternative UPACC:
P49005; A4D2J4; B2R5S4
Background:
DNA polymerase delta subunit 2, also known as DNA polymerase delta subunit p50, plays a pivotal role in high fidelity genome replication and repair. It is a crucial component of the DNA polymerase delta complex, involved in lagging strand synthesis, and exhibits significant differences in catalytic activity depending on its assembly. This protein is essential for the repair of broken replication forks and nucleotide excision repair synthesis following UV irradiation, showcasing its versatility in maintaining genome integrity.
Therapeutic significance:
Understanding the role of DNA polymerase delta subunit 2 could open doors to potential therapeutic strategies. Its involvement in genome replication and repair mechanisms highlights its potential as a target for developing treatments aimed at enhancing DNA repair pathways, crucial for combating genetic diseases and improving responses to DNA-damaging agents.