Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49326
UPID:
FMO5_HUMAN
Alternative names:
Baeyer-Villiger monooxygenase 1; Dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline oxidase 5; NADPH oxidase
Alternative UPACC:
P49326; B2RBG1; C9JJD1; Q8IV22
Background:
Flavin-containing monooxygenase 5 (FMO5), known for its Baeyer-Villiger monooxygenase activity, catalyzes the oxygenation of a wide range of substrates, transforming ketones into esters. Unlike other FMOs, FMO5 exhibits limited activity on conventional substrates like drugs and pesticides, focusing instead on carbonyl compounds. It also demonstrates NADPH oxidase activity and influences cholesterol biosynthesis and glucose homeostasis, hinting at a role in metabolic aging.
Therapeutic significance:
Understanding the role of Flavin-containing monooxygenase 5 could open doors to potential therapeutic strategies, especially in modulating metabolic processes and aging.