Focused On-demand Library for Protein farnesyltransferase subunit beta

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

P49356

UPID:

FNTB_HUMAN

Alternative names:

CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta

Alternative UPACC:

P49356; B2RDX6; B4E1A0

Background:

Protein farnesyltransferase subunit beta, also known as CAAX farnesyltransferase subunit beta or Ras proteins prenyltransferase subunit beta, plays a pivotal role in the post-translational modification of proteins. It catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine residue near the C-terminus of target proteins, a process crucial for their proper function and localization.

Therapeutic significance:

Understanding the role of Protein farnesyltransferase subunit beta could open doors to potential therapeutic strategies. Its involvement in the modification of proteins essential for cell signaling and growth positions it as a key target in the development of treatments for diseases where these processes are dysregulated.