Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P49427
UPID:
UB2R1_HUMAN
Alternative names:
(E3-independent) E2 ubiquitin-conjugating enzyme R1; E2 ubiquitin-conjugating enzyme R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Alternative UPACC:
P49427; A8K689
Background:
Ubiquitin-conjugating enzyme E2 R1, known for its pivotal role in protein ubiquitination, facilitates the covalent attachment of ubiquitin to target proteins, a process critical for cellular regulation. This enzyme is instrumental in 'Lys-48'-linked polyubiquitination, influencing protein degradation via the proteasome pathway. It collaborates with E2 UBCH5C and SCF(FBXW11) for NFKBIA degradation, and with SCF(SKP2) in cell proliferation by targeting MYBL2 and KIP1. Additionally, it plays a role in the cell cycle, particularly in the G2/M phase by targeting WEE1 kinase.
Therapeutic significance:
Understanding the role of Ubiquitin-conjugating enzyme E2 R1 could open doors to potential therapeutic strategies.