Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49675
UPID:
STAR_HUMAN
Alternative names:
START domain-containing protein 1
Alternative UPACC:
P49675; Q16396
Background:
Steroidogenic acute regulatory protein, mitochondrial, also known as START domain-containing protein 1, is pivotal in steroid hormone synthesis. It facilitates the conversion of cholesterol into pregnenolone, a precursor for all steroid hormones, by mediating cholesterol transfer within mitochondria.
Therapeutic significance:
Its critical role in adrenal hyperplasia 1, a severe condition marked by adrenocortical insufficiency and potential infant mortality, underscores the importance of this protein in disease. Understanding its function could lead to novel treatments for adrenal hyperplasia and related disorders.