Focused On-demand Library for Ras-related protein Rab-27A

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

GTP-binding protein Ram

Alternative UPACC:

P51159; O00195; Q6FI40; Q9UIR9; Q9Y5U3


Ras-related protein Rab-27A, also known as GTP-binding protein Ram, plays a pivotal role in cellular processes. It oscillates between active GTP-bound and inactive GDP-bound states, influencing the late endocytic pathway, including endosomal positioning, maturation, and secretion. Additionally, it is crucial for cytotoxic granule exocytosis in lymphocytes, essential for granule maturation and docking at the immunologic synapse.

Therapeutic significance:

Rab-27A's involvement in Griscelli syndrome 2, a rare autosomal recessive disorder characterized by pigmentary dilution, hair shaft pigment clumps, and potentially fatal hemophagocytic syndrome, underscores its therapeutic significance. Targeting Rab-27A could offer novel treatment avenues for managing this syndrome and its associated neurological impairments.

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