Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P51511
UPID:
MMP15_HUMAN
Alternative names:
Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; SMCP-2
Alternative UPACC:
P51511; A0A2U6; Q14111
Background:
Matrix metalloproteinase-15, also known as Membrane-type matrix metalloproteinase 2, plays a crucial role in the degradation of extracellular matrix components. This endopeptidase's ability to activate progelatinase A underscores its significance in cellular processes.
Therapeutic significance:
Understanding the role of Matrix metalloproteinase-15 could open doors to potential therapeutic strategies. Its involvement in the extracellular matrix remodeling suggests its potential in targeting diseases related to tissue regeneration and fibrosis.