Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P53365
UPID:
ARFP2_HUMAN
Alternative names:
ADP-ribosylation factor-interacting protein 2; Partner of RAC1
Alternative UPACC:
P53365; B4DX86; B4E306; D3DQT5
Background:
Arfaptin-2, also known as ADP-ribosylation factor-interacting protein 2 and Partner of RAC1, is a pivotal protein in cellular processes, including metalloproteinase secretion, autophagy, and mitophagy. It facilitates the secretion of MMPs like MMP7 and MMP2 from the trans Golgi network and plays a crucial role in the trafficking of ATG9A vesicles, essential for autophagosome initiation and phagophore growth during mitophagy. Additionally, Arfaptin-2 is involved in NF-kappa-B inhibition through its interaction with IKBKB and IKBKG.
Therapeutic significance:
Understanding the role of Arfaptin-2 could open doors to potential therapeutic strategies, particularly in diseases where MMP secretion, autophagy, and NF-kappa-B pathways are dysregulated.