Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P53701
UPID:
CCHL_HUMAN
Alternative names:
Cytochrome c-type heme lyase
Alternative UPACC:
P53701; B3KUS1; Q502X8
Background:
Holocytochrome c-type synthase, also known as Cytochrome c-type heme lyase, plays a crucial role in the mitochondrial electron transport chain by catalyzing the attachment of heme to cytochrome c. This process is vital for the production of functional cytochrome c, a key component in cellular energy production.
Therapeutic significance:
Given its involvement in Linear skin defects with multiple congenital anomalies 1 (LSDMCA1), a disorder marked by severe developmental abnormalities, understanding the role of Holocytochrome c-type synthase could open doors to potential therapeutic strategies. Targeting this protein's function might offer insights into treating or managing the disease's complex symptoms.