Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P54284
UPID:
CACB3_HUMAN
Alternative names:
Calcium channel voltage-dependent subunit beta 3
Alternative UPACC:
P54284; A8K0Z4; B7Z4Q1; B7Z973; B7ZAK8; F5GZW7; F5H2P6; F8VSG3; Q13913
Background:
The Voltage-dependent L-type calcium channel subunit beta-3, also known as Calcium channel voltage-dependent subunit beta 3, plays a crucial role in the regulation of voltage-gated calcium channels. It enhances the peak calcium current of CACNA1B and CACNA1C channels, modulating their activation and inactivation dynamics. This protein's function is pivotal in the transmission of calcium ions across cell membranes, influencing various cellular processes.
Therapeutic significance:
Understanding the role of Voltage-dependent L-type calcium channel subunit beta-3 could open doors to potential therapeutic strategies. Its involvement in modulating calcium currents makes it a significant target for research in diseases where calcium ion dysregulation is a factor.