Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P55055
UPID:
NR1H2_HUMAN
Alternative names:
Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
Alternative UPACC:
P55055; A8K490; B4DNM6; E7EWA6; Q12970; Q5I0Y1
Background:
Oxysterols receptor LXR-beta, also known as Liver X receptor beta, plays a pivotal role in cholesterol homeostasis, lipid metabolism, and inflammatory processes. It functions by binding to specific DNA sequences, regulating the expression of genes involved in lipid uptake, and modulating the inflammatory response in hepatocytes. Its activity is enhanced by ligands and involves critical interactions with proteins such as MYLIP for LDLR regulation, and LPCAT3 for lipid remodeling.
Therapeutic significance:
Understanding the role of Oxysterols receptor LXR-beta could open doors to potential therapeutic strategies. Its involvement in lipid metabolism and inflammation highlights its potential as a target for treating metabolic disorders and inflammatory diseases. The receptor's ability to modulate cholesterol levels and inflammatory responses presents a promising avenue for drug discovery aimed at cardiovascular diseases and liver conditions.