Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P55316
UPID:
FOXG1_HUMAN
Alternative names:
Brain factor 1; Brain factor 2; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3
Alternative UPACC:
P55316; A6NFY2; P55315; Q14488; Q86XT7
Background:
Forkhead box protein G1, known by alternative names such as Brain factor 1 and Forkhead-related protein FKHL1, plays a pivotal role in brain development and the establishment of the telencephalon's regional subdivision. Its involvement in transcription repression underscores its significance in neurodevelopment.
Therapeutic significance:
Linked to the congenital variant of Rett syndrome, Forkhead box protein G1's mutation highlights its critical role in severe neurodevelopmental disorders. Understanding its function could pave the way for innovative therapeutic strategies targeting early-onset neurodevelopmental conditions.