Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P56282
UPID:
DPOE2_HUMAN
Alternative names:
DNA polymerase II subunit 2; DNA polymerase epsilon subunit B
Alternative UPACC:
P56282; A0AV55; A4FU92; A4LBB7; A6NH58; B4DDE6; O43560
Background:
DNA polymerase epsilon subunit 2, also known as DNA polymerase II subunit 2 or DNA polymerase epsilon subunit B, plays a crucial role in DNA repair and chromosomal DNA replication. As an accessory component of the DNA polymerase epsilon complex, it ensures the accuracy and efficiency of DNA synthesis, which is fundamental for cellular function and genomic integrity.
Therapeutic significance:
Understanding the role of DNA polymerase epsilon subunit 2 could open doors to potential therapeutic strategies. Its involvement in DNA replication and repair mechanisms positions it as a key target for developing treatments aimed at enhancing genomic stability in diseases characterized by DNA repair deficiencies.