Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P56373
UPID:
P2RX3_HUMAN
Alternative names:
ATP receptor; Purinergic receptor
Alternative UPACC:
P56373; Q6DK37; Q9UQB6
Background:
P2X purinoceptor 3, also known as ATP receptor or Purinergic receptor, is a key player in the body's sensory system. Acting as a ligand-gated cation channel, it facilitates the flow of ions across the cell membrane in response to ATP binding. This protein is essential for the normal perception of pain and taste, highlighting its critical role in sensory experiences.
Therapeutic significance:
Understanding the role of P2X purinoceptor 3 could open doors to potential therapeutic strategies. Its pivotal function in pain perception makes it a promising target for developing novel pain management therapies, offering hope for individuals suffering from chronic pain conditions.