Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P56704
UPID:
WNT3A_HUMAN
Alternative names:
-
Alternative UPACC:
P56704; Q3SY79; Q3SY80; Q969P2
Background:
Protein Wnt-3a, encoded by the gene P56704, is a pivotal component in the Wnt signaling pathway, crucial for embryonic development, including mesoderm formation and neural tube morphogenesis. It acts as a ligand for frizzled family receptors, activating TCF/LEF transcription factors, and is essential for the self-renewal of intestinal stem cells.
Therapeutic significance:
Understanding the role of Protein Wnt-3a could open doors to potential therapeutic strategies, particularly in regenerative medicine and developmental disorders. Its involvement in stem cell renewal highlights its potential in tissue engineering and cancer treatment.