Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P57772
UPID:
SELB_HUMAN
Alternative names:
Elongation factor sec; Eukaryotic elongation factor, selenocysteine-tRNA-specific
Alternative UPACC:
P57772; Q96HZ6
Background:
The Selenocysteine-specific elongation factor, known as Elongation factor sec or Eukaryotic elongation factor, selenocysteine-tRNA-specific, plays a pivotal role in protein synthesis. It is essential for the incorporation of selenocysteine into proteins, facilitated by its ability to bind GTP and GDP, and is directed by the UGA codon. This unique mechanism distinguishes it from the conventional EF-Tu elongation factor, underscoring its specialized function in cellular biology.
Therapeutic significance:
Understanding the role of Selenocysteine-specific elongation factor could open doors to potential therapeutic strategies. Its critical function in protein synthesis and the unique mechanism of selenocysteine incorporation highlight its potential as a target for drug discovery, aiming to modulate protein synthesis pathways for therapeutic benefits.