Focused On-demand Library for Endoribonuclease YbeY

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.

Our library stands out due to several important features:

The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

P58557

UPID:

YBEY_HUMAN

Alternative names:

Alternative UPACC:

P58557; B7WPA9; B7WPF7; D3DSN2

Background:

Endoribonuclease YbeY is a single strand-specific metallo-endoribonuclease crucial for rRNA maturation. Its unique enzymatic activity underscores its importance in the precise processing of ribosomal RNA, a fundamental process for protein synthesis in all living cells. This protein's role is pivotal in the intricate network of molecular interactions that facilitate cellular function and genetic expression.

Therapeutic significance:

Understanding the role of Endoribonuclease YbeY could open doors to potential therapeutic strategies. Its central function in rRNA maturation positions it as a key target for interventions aimed at diseases linked to ribosomal dysfunction and protein synthesis anomalies. Exploring its mechanisms further could yield novel insights into treating such conditions.