Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P59540
UPID:
T2R46_HUMAN
Alternative names:
Taste receptor type 2 member 54
Alternative UPACC:
P59540; P59548; Q645X6
Background:
Taste receptor type 2 member 46, alternatively known as Taste receptor type 2 member 54, plays a crucial role in the perception of bitterness and the chemical composition of the gastrointestinal content. Its activation may stimulate alpha gustducin, lead to PLC-beta-2 activation, and gate TRPM5. Additionally, in airway epithelial cells, it responds to bitter compounds by increasing intracellular calcium ion concentration and enhancing ciliary beat frequency.
Therapeutic significance:
Understanding the role of Taste receptor type 2 member 46 could open doors to potential therapeutic strategies.