Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P61513
UPID:
RL37A_HUMAN
Alternative names:
60S ribosomal protein L37a
Alternative UPACC:
P61513; P12751; Q6FGF5
Background:
The Large ribosomal subunit protein eL43, also known as 60S ribosomal protein L37a, is a crucial component of the ribosome. This protein plays a pivotal role in the synthesis of proteins within the cell, as part of the larger ribonucleoprotein complex. Its presence is essential for the accurate and efficient translation of mRNA into polypeptide chains, facilitating cellular function and homeostasis.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein eL43 could open doors to potential therapeutic strategies. Its fundamental involvement in protein synthesis positions it as a potential target for interventions in diseases where protein production is dysregulated.