Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P61626
UPID:
LYSC_HUMAN
Alternative names:
1,4-beta-N-acetylmuramidase C
Alternative UPACC:
P61626; P00695; Q13170; Q9UCF8
Background:
Lysozyme C, also known as 1,4-beta-N-acetylmuramidase C, plays a crucial role in the body's defense mechanism. Its primary function is bacteriolytic, breaking down bacterial cell walls, particularly in association with the monocyte-macrophage system. This enhances the activity of immune agents, showcasing its vital role in the immune response.
Therapeutic significance:
Amyloidosis 8, a hereditary generalized amyloidosis, is linked to Lysozyme C. This disease features extensive visceral amyloid deposits and renal amyloidosis, leading to nephrotic syndrome, among other symptoms. Understanding the role of Lysozyme C could open doors to potential therapeutic strategies for treating Amyloidosis 8 and improving patient outcomes.