Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P61923
UPID:
COPZ1_HUMAN
Alternative names:
Zeta-1-coat protein
Alternative UPACC:
P61923; B4DDX8; B4DHZ0; F8VS17; F8VWL5; Q549N6; Q9Y3C3
Background:
The Coatomer subunit zeta-1, also known as Zeta-1-coat protein, plays a pivotal role in cellular transport mechanisms. It is a part of the coatomer complex, essential for the transport of biosynthetic proteins from the ER through the Golgi apparatus to the trans Golgi network. This protein binds to dilysine motifs and is crucial for the budding from Golgi membranes, facilitating the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Therapeutic significance:
Understanding the role of Coatomer subunit zeta-1 could open doors to potential therapeutic strategies. Its involvement in protein transport processes makes it a significant target for research aimed at uncovering novel drug discovery avenues.