Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P61966
UPID:
AP1S1_HUMAN
Alternative names:
Adaptor protein complex AP-1 subunit sigma-1A; Adaptor-related protein complex 1 subunit sigma-1A; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; Sigma1A-adaptin
Alternative UPACC:
P61966; B2R5D8; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9
Background:
The AP-1 complex subunit sigma-1A, known by various names such as Adaptor protein complex AP-1 subunit sigma-1A and Clathrin assembly protein complex 1 sigma-1A small chain, plays a crucial role in protein sorting within the late-Golgi/trans-Golgi network (TGN) and/or endosomes. This protein is integral to the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Therapeutic significance:
AP-1 complex subunit sigma-1A is implicated in MEDNIK syndrome, a disorder marked by a spectrum of symptoms including erythematous skin lesions, hyperkeratosis, and severe psychomotor retardation, among others. Understanding the role of AP-1 complex subunit sigma-1A could open doors to potential therapeutic strategies for this syndrome.