Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P62195
UPID:
PRS8_HUMAN
Alternative names:
26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; p45/SUG
Alternative UPACC:
P62195; A8K3Z3; A8K763; O35051; O43208; P47210; P52915; P52916
Background:
The 26S proteasome regulatory subunit 8, known as PSMC5, is a crucial component of the 26S proteasome. This multiprotein complex is essential for the ATP-dependent degradation of ubiquitinated proteins, playing a pivotal role in maintaining protein homeostasis. By eliminating misfolded or damaged proteins and those no longer needed, the proteasome ensures cellular functions are not impaired. PSMC5 is part of the AAA (ATPases associated with diverse cellular activities) protein ring, responsible for unfolding and translocating target proteins into a proteolytic chamber for degradation.
Therapeutic significance:
Understanding the role of 26S proteasome regulatory subunit 8 could open doors to potential therapeutic strategies.