Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P62807
UPID:
H2B1C_HUMAN
Alternative names:
Histone H2B.1 A; Histone H2B.a; Histone H2B.g; Histone H2B.h; Histone H2B.k; Histone H2B.l
Alternative UPACC:
P62807; P02278; Q3B872; Q4VB69; Q93078; Q93080
Background:
Histone H2B type 1-C/E/F/G/I, known by alternative names such as Histone H2B.1 A and Histone H2B.a, plays a pivotal role in DNA packaging into chromatin, influencing transcription regulation, DNA repair, replication, and chromosomal stability. Its function extends to forming an antimicrobial barrier in the colonic epithelium and contributing to the bactericidal activity of amniotic fluid.
Therapeutic significance:
Understanding the role of Histone H2B type 1-C/E/F/G/I could open doors to potential therapeutic strategies, particularly in the realm of gene expression regulation and innate immunity.