Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P62857
UPID:
RS28_HUMAN
Alternative names:
40S ribosomal protein S28
Alternative UPACC:
P62857; P25112
Background:
Small ribosomal subunit protein eS28, also known as 40S ribosomal protein S28, plays a crucial role in protein synthesis. It is a component of the small ribosomal subunit, essential for the synthesis of proteins within the cell. This protein is involved in the assembly of the SSU processome in the nucleolus, facilitating RNA folding, modifications, rearrangements, and cleavage, crucial for ribosome biogenesis.
Therapeutic significance:
Small ribosomal subunit protein eS28 is linked to Diamond-Blackfan anemia 15, with mandibulofacial dysostosis, a condition characterized by congenital non-regenerative hypoplastic anemia. Understanding the role of Small ribosomal subunit protein eS28 could open doors to potential therapeutic strategies for this and related disorders.