Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P62987
UPID:
RL40_HUMAN
Alternative names:
CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1
Alternative UPACC:
P62987; P02248; P02249; P02250; P14793; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7
Background:
Ubiquitin-ribosomal protein eL40 fusion protein, also known as CEP52 or Ubiquitin A-52 residue ribosomal protein fusion product 1, plays a pivotal role in cellular processes. It exists in various forms, either attached to proteins or free, influencing DNA repair, cell cycle regulation, stress response, kinase modification, and protein degradation. Additionally, as part of the 60S ribosomal subunit, it is crucial for translation, particularly in virus mRNA processing.
Therapeutic significance:
Understanding the role of Ubiquitin-ribosomal protein eL40 fusion protein could open doors to potential therapeutic strategies.