Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P63010
UPID:
AP2B1_HUMAN
Alternative names:
AP105B; Adaptor protein complex AP-2 subunit beta; Adaptor-related protein complex 2 subunit beta; Beta-2-adaptin; Beta-adaptin; Clathrin assembly protein complex 2 beta large chain; Plasma membrane adaptor HA2/AP2 adaptin beta subunit
Alternative UPACC:
P63010; A6NJP3; P21851; Q7Z451; Q96J19
Background:
The AP-2 complex subunit beta, known by various names such as Beta-2-adaptin and Clathrin assembly protein complex 2 beta large chain, plays a pivotal role in clathrin-dependent endocytosis. This process is crucial for the internalization of membrane proteins, with AP-2 acting as a cargo receptor for their selective sorting. It recognizes specific motifs within the cytosolic tails of transmembrane cargo molecules, facilitating their incorporation into vesicles for transport to the early endosome. AP-2's involvement extends to synaptic vesicle membrane recycling and may influence post-endocytic trafficking through non-clathrin pathways.
Therapeutic significance:
Understanding the role of AP-2 complex subunit beta could open doors to potential therapeutic strategies.