Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P63124
UPID:
VPK04_HUMAN
Alternative names:
HERV-K104 Pro protein; HERV-K_5q13.3 provirus ancestral Pro protein; Protease; Proteinase
Alternative UPACC:
P63124
Background:
The Endogenous retrovirus group K member 104 Pro protein, known by alternative names such as HERV-K104 Pro protein and Protease, plays a crucial role in the life cycle of retroviruses. It is involved in the processing of primary translation products and the maturation of viral particles. This protein's evolutionary journey suggests it may have retained, lost, or modified its original function, highlighting its adaptability and significance in viral evolution.
Therapeutic significance:
Understanding the role of Endogenous retrovirus group K member 104 Pro protein could open doors to potential therapeutic strategies. Its involvement in the maturation of viral particles makes it a target for antiviral drug development, offering a promising avenue for the treatment of retrovirus-related diseases.